Question

Although it is not the primary flux-control point for glycolysis, pyruvate kinase is subject to allosteric regulation. What is the metabolic importance of regulating flux through the pyruvate kinase reaction?

Answer 1

For the control of flux of metabolites (like fructose) to the glycolysis pathway.

Step-by-step explanation:

Pyruvate kinase regulation is important because it help in the controlling the continuous movement or flow of metabolites such as fructose in the liver. This fructose that enters glycolysis pathways after the PFK step.

Answer 2

Pyruvate kinase is the important enzyme that catalyzes the conversion of phosphoenol pyruvate into the pyruvate in the glycolysis cycle. This step generates the ATP molecule.

The regulation of the pyruvate kinase is done by the allosteric regulation and fructose 1,6 biphosphate activates the pyruvate kinase. This regulation is important as it control the metabolites present in different organs. The metabolites like fructose, galactose enters in the glycolysis from the liver after the particlar step of glycolysis.