1. mRNA of normal haemoglobin: 5'CCU CUC CUC 3'
mRNA of abnormal haemoglobin: 5'CCU GUG CUG 3'
2. Amino acid sequence of normal haemoglobin: Proline, Leucine, Leucine
Amino acid sequence of abnormal haemoglobin: Proline, valine, Leucine.
3. The DNA will undergo transcription forming mRNA and then mRNA will undergo Translation to form proteins.
Step-by-step explanation:
The mRNA is coded from 3' to 5' strand of DNA and forming 5'to3' strand of mRNA.
The set of 3 base pairs of mRNA codes for an amino acid.
The mRNA is formed from the DNA by the process of Transcription which takes place in the nucleus. The primary enzyme which adds nucleotide complementary to the DNA is RNA Polymerase. It is a DNA based gene expression. The mRNA form is single-stranded. It undergoes process of 5'mRNA capping and polyadenylation.
After this, it will be transported to the cytoplasm where protein machinery ribosome is there. The Ribosome can be free or with theendoplasmic reticulum. tRNA brings the amino acids to the growing polypeptide chain and stops when encounters a stop codon. Also, the polypeptide starts when tRNA encounters start codon. The polypeptide chain formed will be taken to Golgi apparatus for sorting, packaging and secretion of the protein formed.
Any protein like haemoglobin will be formed this way only while abnormal protein for abnormal haemoglobin will have the mutation at the DNA level which will encode faulty base pair and hence the different amino acid leading to different protein.