Question

Changing a single amino acid in a protein consisting of 325 amino acids would _____.

Answer 1

Changing a single amino acid in a protein can result in major changes to the protein's structure and function, potentially leading to diseases such as sickle-cell anemia, or stopping protein production entirely in the case of nonsense mutations.

Step-by-step explanation:

Changing a single amino acid in a protein consisting of 325 amino acids can have a significant impact on the protein's structure and function due to a type of mutation known as a missense mutation. Such a change in the sequence can lead to diseases, such as sickle-cell anemia, which is caused by a single amino acid substitution in the hemoglobin protein. This substitution of valine for glutamic acid in the hemoglobin leads to a major alteration in the protein's properties and the person's health. Not all amino acid substitutions result in such severe outcomes, as the effect depends on the location within the protein and the roles of the affected amino acid. Additionally, mutations like nonsense mutations can lead to a complete loss of function if they introduce a premature stop codon, halting the production of the entire protein.

Answer 2

Answer: affect the primary structure and cause a change in the biological activity of Protein.

Step-by-step explanation:

Gene replication, transcription and translation are highly specific.

A single change in the nucleotide always alter the primary structure of the protein, a specific amino acid sequence in a polypeptide can denotes its primary structure. Sometimes alter the tertiary structure of the protein. When the structure of the protein is affected it will affect its biological activity.