Question

In its attempt to suppress allergic responses, the body releases several chemicals which have a role in mediating physical reactions. Epinephrine, which interferes with vasoactive chemical release from mast cells, is instrumental in suppressing which type of hypersensitivity response?a. type Ib. type IIc. type IIId. type IV

Answer 1

a. Type 1 hypersensistivity response.

Step-by-step explanation:

IgE antibodies related to an antigen are produced by stimulated B cells in type 1 hypersenstivty. IgE signalling results in mast cell degranulation and this leads to vasodilation. Histamines, Leucotriens and Prostaglandins are some of the Vasoactive compounds released by Mast cells. Type 1 hypersenstivity is usually treated wit adrenaline (epinephrine).

Epinephrine increases peripheral resistance by stimulatingof α adrenoceptorsvascular thus improving blood pressure and coronary perfusion, reversing peripheral vasodilation, and decreasing angioedema. Stimulation of β2 receptors causes bronchodilation as well as increasing intracellular cyclic adenosine monophosphate production in mast cells and basophils, reducing release of inflammatory mediators and thus reducing the effect caused by mast cells.