Question

Suppose there is a mutation in a laminin­binding integrin gene that causes a loss of function in thecytoplasmic domains of the integrin. Which of the following would you expect to observe as a result ofthis mutation?A.Tissues would be weakened because the integrin could no longer associate with microfilamentsin adherens junctions.B.The integrin would be unable to signal the cytoplasm when it had bound to the laminin.C.Cell adhesion to laminin would decrease, but laminin­mediated gene expression would remainthe same.D.The integrin would function normally because the cytoplasmic domain is not responsible forbinding to laminin.

Answer 1

Answer: The integrin would be unable to signal the cytoplasm when it had bound to laminin. (Option B)

Explanation: Mutation (i.e change/alteration in the genetic sequence) in a laminin­ binding integrin gene causes a loss of laminin based functions in the cytoplasm.

The integrin will only bind to laminin in the cytoplasm, because there is alteration in the DNA sequence which codes for initiation of action in the cytoplasm.