Question

The ΔG° of the hydrolysis reaction of ATP is –7.3 kcal/mole, but in a cell the actual ΔG is much more negative. What is the reason for the ΔG° and ΔG difference?

Answer 1

ΔG° is for ideal (fixed) or standard conditions which cannot be found at the cellular level while ΔG is dependent on the quantities of reactants and products present at a specific time

Step-by-step explanation:

ΔG° is fixed value for a given reaction that indicates the direction in which the reaction will proceed in a chemical equation under ideal conditions and because conditions within a cell varies and are unlike standard conditions, ΔG° cannot predict the direction of a cellular reaction at any given time. To predict the direction of progression of a reaction within the cell, ΔG is used, which depends on the amounts of the reactants and products present at a particular time