Final answer:
The exact percentage of the average state's budget spent on substance use disorders is not specified in the provided data, but healthcare, which includes related costs, is a major state expense at 36%.
Step-by-step explanation:
The direct and indirect cost of substance use disorders is not specifically broken down as a percentage of the average state’s budget in the provided information. However, considering the relevant data, healthcare is a significant expenditure for states, with an average of 36% of state budgets allocated to this area. Substance use disorders would fall under this category, as they require medical care and public health interventions. The interconnectedness of these expenses suggests that substance use disorders likely contribute to a considerable portion of healthcare costs, but an exact percentage cannot be determined without more precise data.