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Based on the information given in the three different sections, which of the following statement(s) correctly describe(s) the hit that is most similar to the query sequence? Select all that apply.

1 Answer

6 votes

NOTE: QUESTION IS INCOMPLETE I HAVE ADDED FULL QUESTION IN THE ASK FOR DETAIL SECTION.

Answer:

Followings are the true options:

  1. It is identical to the query sequence in length and amino acid sequence.
  2. It is a chimeric protein.
  3. Its accession number is CAM33009.1.

Step-by-step explanation:

This question is about sequence analysis. I have retrieved full sequence from National Center for Biotechnology Information (NCBI) library. I used accession number CAM33009.1 which is true and exist on NCBI data base.

Here is the full detail about it.:

Name: bcr-abl1 e13a3 chimeric protein, partial [Homo sapiens]

human

No of Proteins: 235 aa protein

Accession Number: CAM33009.1

LOCUS CAM33009 235 aa linear PRI 14-JUL-2016

DEFINITION bcr-abl1 e13a3 chimeric protein, partial [Homo sapiens].

ACCESSION CAM33009

VERSION CAM33009.1

DBSOURCE embl accession AM491359.1

KEYWORDS .

SOURCE Homo sapiens (human)

ORGANISM Homo sapiens

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;

Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;

Catarrhini; Hominidae; Homo.

REFERENCE 1

AUTHORS Burmeister,T. and Reinhardt,R.

TITLE A multiplex PCR for improved detection of typical and atypical

BCR-ABL fusion transcripts

JOURNAL Leuk. Res. 32 (4), 579-585 (2008)

PUBMED 17928051

REFERENCE 2 (residues 1 to 235)

AUTHORS Burmeister,T.

TITLE Direct Submission

JOURNAL Submitted (02-FEB-2007) Burmeister T., Medizinische Klinik III,

Charite Universitaetsmedizin Berlin, CBF, Hindenburgdamm 30, 12200

Berlin, GERMANY

FEATURES Location/Qualifiers

source 1..235

/organism="Homo sapiens"

/db_xref="taxon:9606"

/cell_type="leukocyte"

/note="fusion of BCR exon 13 and ABL1 exon 3"

Protein <1..>235

/product="bcr-abl1 e13a3 chimeric protein"

/function="tyrosine kinase, oncogene"

Region <1..48

/region_name="PH-like"

/note="Pleckstrin homology-like domain; cl17171"

/db_xref="CDD:302622"

Region <72..107

/region_name="SH3"

/note="Src Homology 3 domain superfamily; cl17036"

/db_xref="CDD:302595"

Region 112..205

/region_name="SH2_ABL"

/note="Src homology 2 (SH2) domain found in Abelson murine

lymphosarcoma virus (ABL) proteins; cd09935"

/db_xref="CDD:198189"

Site order(123,151,164)

/site_type="other"

/note="phosphotyrosine binding pocket [polypeptide

binding]"

/db_xref="CDD:198189"

CDS 1..235

/gene="BCR-ABL1"

/coded_by="AM491359.1:<1..>707"

/db_xref="GOA:A2RQD3"

/db_xref="InterPro:IPR000980"

/db_xref="InterPro:IPR001452"

/db_xref="InterPro:IPR001849"

/db_xref="InterPro:IPR020685"

/db_xref="InterPro:IPR020700"

/db_xref="UniProtKB/TrEMBL:A2RQD3"

ORIGIN

1 psmafrvhsr ngksytflis sdyeraewre nireqqkkcf rsfsltsvel qmltnscvkl

61 qtvhsiplti nkegeklrvl gynhngewce aqtkngqgwv psnyitpans lekhswyhgp

121 vsrnaaeyll ssgingsflv resesspgqr sislryegrv yhyrintasd gklyvssesr

181 fntlaelvhh hstvadglit tlhypapkrn kptvygvspn ydkwemertd itmkh

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