Answer:
In multicellular organisms, the mechanism most directly responsible for directing development and maintaining homeostasis is gene "regulation"
Step-by-step explanation:
Even though the organs present throughout the body helps in maintaining the homeostasis, But the systems like endocrine system and nervous system plays important role in sustaining and regulating it. The gene regulation is the increase and decrease of the specific gene products. Gene regulation can also be understood as the regulating process which helps in controlling ability of the cell to the environmental changes or can say the adaptability of the cell to changing environment done by gene regulation.