Question

A transient shortage of oxygen (global ischemia) releases excess glutamate into the extracellular fluid of the brain. This causes neuronal death by hyperexcitation to a greater extent in the hippocampus than in the cortex. Which reason best explains why the hippocampus is selectively vulnerable during global ischemia?

Answer 1

Step-by-step explanation:

The hippocampus becomes selectively unprotected because the receptor of the NMDA becomes more pronounced in the hippocampus than in the cortical neurons and this leads to a situation where by the hippocampus becomes more exposed to extracellular glutamate whose release is in excess.