Answer:
The answer is the VPg Protein.
Step-by-step explanation:
The question is incomplete, here is the full question:
Poliovirus is a positive-sense RNA virus of the picornavirus group. At its 5' end, the RNA genome has a viral protein (VPg) instead of a 5' cap. This is followed by a nontranslated leader sequence, and then a single long protein coding region (~7,000 nucleotides), followed by a poly-A tail. Observations were made that used radioactive amino acid analogues. Short period use of the radioactive amino acids result in labeling of only very long proteins, while longer periods of labeling result in several different short polypeptides.
What part of the poliovirus would first interact with host cell ribosomes to mediate translation?
A) the poly-A tail
B) the leader sequence
C) the VPg protein
The part of the host cell ribosome that the poliovirus would interact first is the VPg protein because the poliovirus has to affect the RNA to be able to replicate it's own DNA and the VPg protein is attached to the RNA's 5' end.
I hope this helps.