Since the options are not given the question is incomplete and the complete question is as follows:
The fact that DNA sequences are more similar in more closely related organisms is evidence of what?
optimal design in organisms
adaptation
mutation
descent with modification
Answer: descent with modification
Explanation:
The Darwin theory of evolution includes the concept of descent with modification. This indicates that the traits are passed from the parents to offspring. Thus the offspring will show characteristics and perform biological functions like their parents. As the offspring have inherited genes or traits from the parents the two or more offspring are expected to have same traits due to inheritance of similar DNA sequences.