Question

There are 8 diastereomers of1,2,3,4,5,6-hexachlorocyclohexane.

Draw each in its more stablechair conformation. One isomer loses
HCl in an E2 reaction nearly1000x more slowly than the others.
Which isomer reacts so slowly,and why?

Answer 1

answer can be seen in the attached file

Step-by-step explanation:

There are 8 diastereomers of1,2,3,4,5,6-hexachlorocyclohexane.

Draw each in its more stablechair conformation. One isomer loses

HCl in an E2 reaction nearly 1000x more slowly than the others.

Which isomer reacts so slowly,and why?

8 diastereomers of 1,2,3,4,5,6-hexachlorocyclohexane in their stable chair conformation.

For E2 Elimination in cyclohexane derivatives the stereoelectronic requirement is that the leaving groups should be both to each other?-isomer. although not possible

The -isomer we are looking for is the only one that does not have any axialchlorines and hydrogen.it reacts nearly 1000x more slowly than the others