Question

Which of the following is FALSE about ribose and nucleotide and

nucleic acid synthesis?
a) Ribose can be synthesized in virtually all tissues
b) Since ribose is not a significant constituent of systemic
blood,tissues must satisfy their own requirement for this important
precursor of nucleotides.
c) It is necessary to have a completely functioning pentose
phosphate pathway for a tissue to synthesize ribose phosphates.
d) The pentose phosphate pathway provides ribose residues for
nucleotide and nucleic acid synthesis.
e) Although muscle tissue contains only very small amounts of
glucose-6- phosphate dehydrogenase and 6-phosphogluconate
dehydrogenase, it is capable, like most other tissues, of
synthesizing ribose 5-phosphate for nucleotide synthesis by a
reversal of the nonoxidative phase of the pentose phosphate pathway
utilizing fructose 6-phosphate.

Answer 1

The correct answer is option c) "It is necessary to have a completely functioning pentose phosphate pathway for a tissue to synthesize ribose phosphates".

Step-by-step explanation:

While the pentose phosphate pathway is the most common way at which a tissue synthesize ribose phosphate, it is false to affirm that it is necessary for ribose phosphate synthesis. Tissues have alternatives to the pentose phosphate pathway to synthesize ribose phosphate. For instance, the nucleotide salvage or the salvage pathway allows tissues to synthesize ribose phosphate from intermediates in the degradative pathway for nucleotides.