Question

Which of the following does not describe local alignment algorithm?

a) Score can be negative
b) Negative score is set to 0
c) First row and first column are set to 0 in initialization step
d) In traceback step, beginning is with the highest score, it ends when 0 is encountered

Answer 1

The answer is "Option a".

Step-by-step explanation:

A score can be detrimental. When an element has a score below zero, it means, that the sequences up to this point have no correlations, that are set to zero and its effects the previous alignment is excluded. Thus, alignment can be further found in every position later in the calculation. and other options are incorrect that can be described as follows:

• In option b, In this option the score can be negative, that's why we can't set its value.
• In option c, The first row and column must contain some value it can't be 0, that's why it is not correct.
• In option d, It will start with a lower score and ends with a higher score, that's why it is not correct.