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Second-generation H1 antagonists cause less CNS depression because they are selective for peripheral H1 receptors and because of which other property?
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Second-generation H1 antagonists cause less CNS depression because they are selective for peripheral H1 receptors and because of which other property?

User Paul P Joby
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Answer:

THEIR INABILITY TO CROSS THE BLOOD-BRAIN BARRIER AT THERAPEUTIC LEVELS.

Step-by-step explanation:

Second-generation antihistamines (e.g., loratadine, terfenadine) lack the ability to pass through the blood-brain barrier at certain therapeutic levels.

User Kevinnls
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