Answer: 96 ways
Explanation: this is a combination.
If the company reps are designated as A, B, C & D.
A can have Handshakes with the rest 3
B can have Handshakes with the rest 2
C can shake hands with D
So 3+2+1=6 multiplied by the total number of reps i.e 16.
So 16x6=96