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What was the main Impact of the Anti-Federalists on the adoption of the US
Constitution?

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Answer:

Their efforts defeated the original Constitution, which had to be completely rewritten for ratification. Their support for a strong central government led to the inclusion of additional presidential powers. Their concern about factions lent support for basing the US government on a representative republic structure. And also their concern for preserving liberty led to the inclusion of the Bill of Rights in the ratified form of the Constitution.

Anti-Federalists were against the strong government and wanted a Bill of Rights as opposed to the Federalists

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