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Answer:
P"(2, -1)
Explanation:
Reflection in the y-axis is described by ...
(x, y) ⇒ (-x, y)
Then your reflected point is ...
P(2, 1) ⇒ P'(-2, 1)
__
Rotation 180° about the origin is described by ...
(x, y) ⇒ (-x, -y)
When the reflected point is then rotated 180° about the origin, it becomes ...
P'(-2, 1) ⇒ P"(2, -1) . . . . reflected and rotated point