Question

The conversion of glucose to glucose 6-phosphate is an enzyme-catalyzed reaction. During this reaction, the enzyme hexokinase folds around the substrates to bring reactive side chains from the active site into alignment with the substrates. This change in hexokinase is an example of

Answer 1

Induced fit

Explanation:

Induced fit (IF) is a model used to understand enzyme-substrate interactions, which can be considered as a development of the classical lock-and-key model. This model (IF) was proposed by Daniel Koshland (1958) in order to understand protein conformational changes during the binding process. The model states that the active site of the enzyme, i.e., the region where the substrate binds and catalyzes the reaction, is reshaped when it binds with its substrate in order to improve the fit. The IF model assumes that the active site of the enzyme is flexible and is capable of changing its shape until the substrate is completely bound.