Answer:
I would say Slavery
Step-by-step explanation:
One example of this is the time after Louisiana Purchase in 1803. Missouri wanted statehood as a slave state. However, the Tallmadge Amendment was proposed where no slaves could be imported, and children born after Missouri's admission are free. Southerners disliked this and the Missouri Compromise was made to admit Missouri as a slave state and Maine as a free state to maintain the northern and southern power in the government.
There are so many times when Congress fought over slavery such as Bleeding Kansas and the Great Compromise of 1850.