Question

Imagine a continuation of the experiment described above. How might NS3/4A expression impact Sendai virus replication, as measured by the amount of virus produced by the different cells? a. Cells expressing NS3/4A will produce more Sendai virus than cells that do not express NS3/4A. b. Cells expressing NS3/4A will produce less Sendai virus than cells that do not express NS3/4A. c. The two types of cells will produce roughly equal amounts of Sendai virus.

Answer 1

The correct answer is - a. Cells expressing more NS3/4a will produce more Sendai virus than cells that do not express NS3/4a.

Step-by-step explanation:

NS3/4a is a multiprotein serine protease that is a non-covalent heterodimer consisting of a catalytic subunit protein. This heterodimer has an N-terminal one-third of NS3 protein and at an activating cofactor (NS4A) protein.

It acts as an antagonist for cytokine promoters. Thus in the absence of cytokines or reduced levels of cytokines due to inactive promoters) the expression of the virus would increase.