Question

Assign priorities in the following set of substituents according to Cahn-Ingold-Prelog rules.

-OCH3 -Br -Cl -CH2OH
А B C D
(Provide your ranking through a string like abcd, starting with the one with the highest priority).

Answer 1

Assign priorities in the following set of substituents according to Cahn-Ingold-Prelog rules.

-OCH3 -Br -Cl -CH2OH

Step-by-step explanation:

To give priorities for the substituents that are attached to chiral carbon and to assign either R or S-configuration the following rules were proposed:

1. The atom with the highest atomic number is given first priority.

2. If the Groups attached to chiral carbon are having the same first atom, then check for the atomic number of the second atom.

Among the given groups,

-Br has the highest atomic number, so it is given first priority.

Then, -Cl.

Then, -OCH3

and the last one is -CH2OH.

Hence, the order is :

BCAD.