Answer:
On March 22, 1622, Powhatan Indians attacked and killed colonists in eastern Virginia. Known as the Jamestown Massacre, the bloodbath gave the English government an excuse to justify their efforts to attack Indians and confiscate their land.
In 1636, the Pequot War over trade expansion broke out between Pequot Indians and English settlers of Massachusetts Bay and Connecticut. The colonists’ Indian allies joined them in battle and helped defeat the Pequot.
A series of battles took place from 1636 to 1659 between New Netherlands settlers in New York and several Indian tribes (Lenape, Susquehannocks, Algonquians, Esopus). Some battles were especially violent and gruesome, sending many settlers fleeing back to the Netherlands.
The Beaver Wars (1640-1701) happened between the French and their Indian allies (Algonquian, Huron) and the powerful Iroquois Confederacy. The fierce fighting started over territory and fur trade dominance around the Great Lakes and ended with the signing of the Great Peace Treaty.