Answer:
directly involved in peripheral vascular disease, stroke, heart disease, diabetes, insulin resistance, chronic kidney failure, tumor growth, metastasis, venous thrombosis, and severe viral infectious diseases.
Nitric oxide has a role in maintaining normal endothelial function through modulation of vascular dilator tone by decreasing endothelin-1, regulation of vascular permeability, platelet aggregation and adherence, and recruitment and adherence of immune cells circulating in the blood
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