Answer: Benjamin Franklin is appealing to the 13 colonies to unite against the French.
Step-by-step explanation:
During the early stages of the French and Indian War, the British were engaged in another war in Europe and so could not adequately protect her colonies in the Americas. This led to the French and their Indian allies attacking and inflicting some defeats on the American colonies.
In response to this, Benjamin Franklin published an article in his newspaper bemoaning the disunity of the colonies. He told them that they needed to unite against the French threat or they would be defeated and wiped out.
The cartoon accompanied the article to show that if the colonies did not come together, they would die but if they united, the snake i.e. them, would live.