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Which claim is most effective for an argumentative essay about the Columbian Exchange?

The Columbian Exchange involved bringing goods to and from two different continents.
The Columbian Exchange involved the exchange of foods, diseases, livestock, and ideas.
The Columbian Exchange was harmful to indigenous peoples because it resulted in disease and death.
The Columbian Exchange is a sad event in history that affected indigenous peoples and should be studied.

User Qstack
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The last one. Columbus was an awful man, tricked Natives out of there money, and almost completely wiped them all out, he killed, and enslaved them.
User Uberwach
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Answer :

D. The Columbian Exchange was harmful to indigenous peoples because it resulted in disease and death."

Believe me !!!!!!
User Gbrennon
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