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Many transcriptional activators are proteins with a DNA -binding domain (DBD) and an activation domain (AD).

a. True
b. False

1 Answer

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Answer:

True

Step-by-step explanation:

Transcriptional activators are proteins that contain domains and/or motifs that bind to DNA in order to induce transcription of specific nearby genes. In general, transcriptional activators enhance the binding with the RNA polymerase complex in order to start transcription. The DNA-binding domains (DBDs) are protein domains that enable a transcriptional activator the binding with enhancers or promoter-proximal elements. Some examples of DBDs include the zinc finger domain, helix-turn-helix domain, leucine zipper domain, etc. On the other hand, the activation domains (ADs) such as, for example, C-terminal activation domains, enable the interaction of the transcriptional activator with coactivators during the formation of the preinitiation complex, thereby transmitting the activating signal to the transcription machinery.

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