Answer:
Areas in Africa.
Step-by-step explanation:
The Bubonic plague or the Black Death was one of the worst pandemics to ravage the world during the 14th century. This plague would lead to the deaths of almost half of the European population during that time.
Believed to be originated from China or Central Asia, the plague spread to other parts of Asia and then to Europe. The entry of the plague into Europe was mainly from the trade routes, through the traders. Moreover, the seaports also contributed to the spread of this plague, moving from one European state to another. One area least affected by it was the areas of Africa. The plague seems to have no impact or entry to the African continent.
Thus, the correct answer is the first option.