The Grafënburg spot is an erogenous region which is located inside the vagina. It is located on the upper wall of the vagina and is usually located 2-3 cm deep. However, there appears to be variation in the perception of Grafënburg spot stimulation amount females. Some women may have trouble finding their g spot due to lack of perception during stimulation, while other women may experience pain and discomfort upon stimulation. This is why communication between sexual partners. By communicating with your partner you can work together in finding the Grafënburg spot, and discuss if stimulation of the area provides satisfaction, or if it is just causing discomfort.
As far as clinical significance, I can not think of any valid reason for a physician to examine the Grafënburg spot, so I suggest that you direct your academic interests to more relevant health related topics.