Question

GRB2 is the protein that links RTK signaling to integrins and focal adhesions. More precisely, focal adhesions sequester GRB2, removing it from the cytoplasm, and thus preventing it from transducing the signal from the RTK to Ras. Based on this information, say something meaningful about focal adhesions, namely something about the domain structure of one of the proteins within them.

Answer 1

It transmit mechanical force and signals.

Step-by-step explanation:

Focal adhesions are large macromolecular which is responsible for the transmission of mechanical force and regulatory signals between the extracellular matrix and an interacting cell. Focal adhesions act as the mechanical linkages to the ECM, and serves as a biochemical signaling hub to direct numerous signaling proteins at sites of integrin binding and clustering. 68-kD protein also known as paxillin is a type of protein which is part of cytoskeletal component that localizes to the focal adhesions.