Question

The following schemes show the design of a peptide-based chemical probe and the proposed mechanism of its activity-based labeling of protein tyrosine phosphatase, an enzyme that is responsible for removing the phosphate from the tyrosine residue(s) of a peptide in a peptide-sequence specific manner. Based your understanding of the schemes and the relevant lecture material, identify the key structural components of this probe that are responsible for (a) binding, (b) covalently modifying, and (c) reporting, respectively.

Answer 1

hello some vital information is missing attached below is the information

answer :

a) nucleophile and alquene carbon.

b) F^- and PO
`_(3)`^- , Nu and C=O

c) fluorescence

Step-by-step explanation:

The key structural components that are responsible for the following are

a)For Binding : the key components responsible for binding are nucleophile and alquene carbon.

b) For Covalently modifying : The key components responsible for covalently Modifying are F^- and PO
`_(3)`^- , Nu and C=O

c) For reporting : The key components responsible for reporting is fluorescence and this is because the as seen in the second structure tyrosine fluorescence is lost