Final answer:
Two wireless keyboards and two wireless mice can be used on a dual monitor setup without interference by ensuring each is paired with its own receiver and leveraging modern operating systems' support for multiple input devices.
Step-by-step explanation:
Yes, you can use two wireless keyboards and two wireless mice on a dual monitor setup without interfering with each other. Modern wireless devices usually operate on different frequencies or channels and can be individually paired with a receiver, either via Bluetooth or a dedicated USB receiver. To avoid interference, make sure each keyboard and mouse set is paired to its own receiver. Moreover, most operating systems support multiple input devices and can handle the signals from each device independently, ensuring that each pair of devices controls only the intended monitor.