Choose three characteristics of enhancers and silencers. Select the three correct statements. Select the three correct statements. Their orientation may be inverted without significant effect. They can act only at a little distance from the promoter. An enhancer can regulate many different genes, while a silencer regulates only one gene or group of closely related genes. They can regulate only one gene or group of closely related genes. They can act at a great distance from the promoter. They can regulate other genes when inserted. They can only act if they are placed downstream from the promoter.