Possible options:
uppercase letter: 26
lowercase letter: 26
number: 10
upper or lowercase letter: 50
Note: I'm interpreting the "no upper or lower case letters can be repeated in the sequence" to mean you could have Aa0b, where A is used as the uppercase and a is used as the lower case letter, but then you can't use A or a for the last character.
26 · 26 · 10 · 50 = 338,000 combinations
Now is using "A" and "a" isn't allowed, then you have:
Possible options:
uppercase letter: 26
lowercase letter: 25
number: 10
upper or lowercase letter: 48
26 · 25 · 10 · 48 = 312,000 combinations