Answer:In this sentence, the word "affect" should be used. The word "affect" is a verb that means to have an influence on or to produce a change in something. In the sentence, Mr. Holmes's speech is having an influence on the speaker, so the correct word to use is "affect."
The word "effect" is a noun that refers to the result or consequence of something. For example, you could say "The effect of Mr. Holmes's speech on me was very powerful." In this sentence, "effect" is used to refer to the result or consequence of Mr. Holmes's speech on the speaker.
In summary, the correct word to use in the sentence "Mr. Holmes's speech on how to make change in the world really me" is "affect," as it is a verb that means to have an influence on or to produce a change in something.
Step-by-step explanation: