Question

a bacterium has a special need for 6-phosphogluconate. what precursors and possible cofactors are needed in the most efficient (fewer number of enzymes) to generate this? (if multiple substrates would be created, assume they can be easily recycled.) products from nucleic acid catabolism intermediates from glycolysis glucose-6-phosphate from glycogen and nadp glucose-6-phosphate from glycogen and nadph products from nucleic acid catabolism and nadph

Answer 1

To generate 6-phosphogluconate, the bacterium would need precursors from nucleic acid catabolism and intermediates from glycolysis. The bacterium would also need the cofactors NADP and NADPH. These precursors and cofactors can be obtained from the breakdown of glycogen, as well as from the catabolism of nucleic acids. In the most efficient pathway, the bacterium would use enzymes to convert these precursors and cofactors into 6-phosphogluconate. It is possible that additional enzymes and cofactors may be needed in this process, depending on the specific requirements of the bacterium.