There were several differences between northern and southern Carolina. One of the main differences was that geographically, the northern part never fit in with the southern part of Carolina. In northern Carolina it was mostly populated by farmers that sold tobacco which was their primary crop. Many of the early settlers had come from Virginia and used their ports, because they did not have easy access to the southerner’s ports. The biggest difference between the north and south was that the south used slaves from Africa to farm the big plantations they had.