Question

Finn listed two of the three steps involved in gene therapy. 1. The normal allele is removed from the chromosome. 2. The normal allele is added to the cells of a person with the disorder. Which step should he also include, and where?

Answer 1

The unhealthy gene sequence is cut from the DNA before 2

Step-by-step explanation:

how can you add a normal one if one is still infected it would be pointless not to take it out

Answer 2

The unhealthy gene sequence is cut from the DNA before 2

Step-by-step explanation:

Gene therapy refers to genetic engineering techniques aimed at introducing exogenous nucleic acids (either DNA or RNA) into the patient's cells in order to restore gene function. Gene therapy techniques hold a great promise to treat genetic diseases and disorders. Gene therapy may involve replacing defective genes with a functional copy of the gene of interest within the desired cells. For this purpose, it is required to use a DNA-specific damaging agent to knock out the defective gene and subsequently restore normal gene function by inserting a functional gene sequence into the recipient cells. Gene therapy techniques can be divided regarding target cells into 1-somatic gene therapy, where genetic modifications are applied on somatic body cells (and therefore they are not inherited by offspring), and 2-germinal gene therapy, where genetic modifications are applied on germinal cells (i.e., gametes) or undifferentiated stem cells (and therefore genetic changes may pass to the following generations).