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Explain how tolerance to nicotine leads to dependence

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Currently, about 45 million Americans smoke tobacco. Seventy percent of smokers say they would like to quit, and every year, 40% do quit for at least 1 day.2 Some highly addicted smokers make serious attempts to quit but are able to stop only for a few hours.3 Moreover, the 80% who attempt to quit on their own return to smoking within a month, and each year, only 3% of smokers quit successfully. Unfortunately, the rate at which persons — primarily children and adolescents — become daily smokers nearly matches the quit rate,
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