Not sure if you're talking about Lorenzo de' Medici or not but, Lorenzo de' Medici had epilepsy. His family also had issues, like economic difficulties with debt-ridden foreign nationals, as well as the Pazzi conspiracy - a revolt by rival banking families backed by the Catholic Church to steal Medici dominance in Florence - had brought the Medici Bank to an end.
If this does not help then next time clarify who you are talking about, thank you.