Question

Use CER to respond to the following prompt.Using the image above (from the source) as evidence, explain how a typical wild type KIT receptor protein (A) works to allow for healthy pigment cell production while each mutated KIT receptor protein (B &C) leads to piebaldism.

Answer 1

Based on the image given the binding of stem cell factor to Kit results in receptor dimerization and activation of protein kinase activity. The activated receptor becomes autophosphorylated at tyrosine residues that serve as docking sites for signal transduction molecules containing SH2 domains.