The sickle cell disease is a group of disorders that affect the hemoglobin, the people with sickle cell disease have atypical hemoglobin called hemoglobin S. If a person is cured of the disease by gene therapy (stem cells or bone marrow transplant), their children will not have the disease. That's happen because the gene therapy is a medical approach that correct the underlying genetic problem by altering the genetic makeup (with functional alleles), therefore the offspring after the disease is cured will not receive the genes for sickle cell disease to their offspring.