Shanice has 4 times as much many pairs of shoes as does her brother Ron, this means

where S is the number of shoes Shanice has and R is the number Ron has.
If Shanice gives Ron 12 pairs of shoes, she will have twice as many pairs of shoes as Ron does. This statement translates to

Now we have two equations and two unknowns which we need to solve for.
Putting in S = 4R into the above equation gives




And therefore, since S = 4R

And since Shanice gives Ron 12 pairs of shoes, the number she will have left will be

Shanice will have left 60 shoes after she gives Ron 12 pairs.
Hence, choice C is the correct one.