Two lines are parallel if they have the same slope, and they are perpendicular if the slope of one is the negative of the reciprocal of the other.
The slope m_1 of the line AB is
![m_1=(2--1)/(3-4)=-3](https://img.qammunity.org/2023/formulas/mathematics/college/zadw9uh764gcfeo6pt28xwzrz2kfe3kul3.png)
And the slope m_2 of the line CD is
![m_2=(-5--4)/(3-6)=(1)/(3)](https://img.qammunity.org/2023/formulas/mathematics/college/a1v09qh192kztnxocb3jiqo2ozb793vsjn.png)
The slopes m_1 and m_2 are negative reciprocals of each other, meaning if you take the reciprocal of m_1 and then multiply it by -1, you will get m_2.
Hence, the lines are perpendicular.