(4, 2) and (8, 1) (option D)
Step-by-step explanation:
The given equation:
y = 4x - 1
comparing with equation of line:
y = mx + c
m = slope = 4
c = y-intercept = -1
For a line to be perpendicular to another line, the slope of one line will be the negative reciprocal of the other line.
We need to find the option which will give a negative reciprocal of 4.

a) (1, -3) and (2, 1)

b) (-4, 7) and (-1, -5)

c) (-8, -4) and (0, -2)

d) (4, 2) and (8, 1)

slope = 4
reciprocal of 4 = 1/4
negative reciprocal = - 1/4
Hence, the option whose slope gives the negative reciprocal of 4 is (4, 2) and (8, 1) (option D)