The correct answer to this open question is the following.
I do not agree with Bolívar about Gran Columbia. I really respect Simon Bolíver, better known as the Great Liberator, and understand what his idea was in those early years of independence from the Spanish crown.
He thought that the vast territory called Gran Columbia would be stronger against any threats, including revenge from the Spanish crown if it remained like that. That is why he created a Constitution to rule that vast territory.
However, there were many differences and interests involved in those regions that conformed Gran Columbia. Let's remember that Gran Columbia was formed by the territories of Colombia, Venezuela, Ecuador, and Panama.
How might South America be different today if his vision had been accepted?
Of course, it had been very different. Gran Columbia would have been a rich and powerful territory for the diversity of its people and natural resources. There would have been many industries exploiting raw materials and exporting them in favorable trade agreements due to the size of the production.