Final answer:
Large mammals domesticated in the Nile River civilization by 1000 BCE included cattle, sheep, goats, and pigs.
Step-by-step explanation:
In the Nile River civilization by 1000 BCE, large mammals that were domesticated included animals such as cattle, sheep, goats, and pigs. These animals were selected for their beneficial characteristics, such as docility, strength, and ability to feed on available foods. Domesticating these animals provided the people with a reliable source of food, raw materials, and labor.