Given that:
- There are a total of 12 students in a homeroom.
- There must be a President, a Vice President, a Treasurer, and a Secretary.
You need to remember the Permutation Formula:

Where "n" is the total number of objects and "r" is the number of objects chosen from the total number.
In this case, you can identify that:

Therefore, substituting values into the formula and evaluating, you get:




Hence, the answer is:
