The total water volume of a healthy adult male is approximately 42 liters, or between 50-65% of his body weight. The total water volume of a healthy adult female is approximately 45-60% of her body weight. Generally, this lower percentage in females is due to a higher fat percentage or a larger fat compartment. Which of the following consequences can occur in female patients taking fat-soluble drugs compared to male patients? (Select all that apply.)
1 It will take more time for the drug to leave the fat compartment.
2 More of the drug will move into the fat compartment.
3 The drug will stay in the body for longer.
4 The drug effects will last longer.